2024

• Neural crest lineage in the protovertebrate model Ciona

Todorov, L.G., Oonuma, K., Kusakabe, T.G. et al.

Nature 635, 912–916 (2024). https://doi.org/10.1038/s41586-024-08111-7

​

• Understanding how cells and organisms keep time during development

Miki Ebisuya, Teresa Rayon, Margarete Diaz-Cuadros, Kevin J. Chalut, Gang Wu, Antony N. Dodd, Maria-Elena Torres-Padilla, Michael Levine, Vadim N. Gladyshev

Developmental Cell, Volume 59, Issue 13, 2024, Pages 1623-1627, ISSN 1534-5807, https://doi.org/10.1016/j.devcel.2024.05.029.

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• Chromosome structure in Drosophila is determined by boundary pairing not loop extrusion

Xinyang Bing, Wenfan Ke, Miki Fujioka, Amina Kurbidaeva, Sarah Levitt, Mike Levine, Paul Schedl, James B Jaynes

2024 eLife 13:RP94070. https://doi.org/10.7554/eLife.94070.3

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• Quantitative proteome dynamics across embryogenesis in a model chordate

Alexander N. Frese, Andrea Mariossi, Michael S. Levine, Martin Wühr

iScience, Volume 27, Issue 4, 2024, 109355, ISSN 2589-0042, https://doi.org/10.1016/j.isci.2024.109355.

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• A blueprint most wonderful, the homeobox discovery.

William McGinnis, Michael Levine

Development 15 March 2024; 151 (6): dev202512. doi: https://doi.org/10.1242/dev.202512

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• What are tethering elements?​

Xiao Li, Michael Levine
Current Opinion in Genetics & Development, Volume 84, 2024, 102151, ISSN 0959-437X, https://doi.org/10.1016/j.gde.2023.102151.

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2023

• Chromosome-level organization of the regulatory genome in the Drosophila nervous system.

Mohana G*, Dorier J*, Li X*, ....., Jankowski A#, Levine M#, Gambetta M#.

Cell 186, no. 18 (2023): 3826-3844.

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• Cereblon influences the timing of muscle differentiation in Ciona tadpoles

J. Long, A. Mariossi, C. Cao, Z. Mo, J.W. Thompson, M.S. Levine, L.A. Lemaire

Proc. Natl. Acad. Sci. U.S.A. 120 (43) e2309989120, https://doi.org/10.1073/pnas.2309989120 (2023).

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• lncRNA read-through regulates the BX-C insulator Fub-1

Airat Ibragimov, Xin Yang Bing, Yulii V Shidlovskii, Michael Levine, Pavel Georgiev, Paul Schedl

2023 eLife 12:e84711. https://doi.org/10.7554/eLife.84711
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• GAGA-associated factor fosters loop formation in the Drosophila genome.

Li X, Tang X, Bing X, Catalano C, Li T, Dolsten G, Wu C, Levine M. 

Molecular Cell 83, no. 9 (2023): 1519-1526.

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• An FGF timer for zygotic genome activation.

Treen N, Chavarria E, Weaver C. J, Brangwynne C. P, Levine M.

Genes & Development, 37(3-4), 80-85.

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•  How do genomes encode developmental time? 

Raimundo J, Levine M.

Genes & Development 37.1-2 (2023): 37-40.

 

2022

• Transcriptional coupling of distant regulatory genes in living embryos.

Levo M*, Raimundo J*, Bing XY, Sisco Z, Batut PJ, Ryabichko S, Gregor T, Levine M.

Nature 2022. https://doi.org/10.1038/s41586-022-04680-7

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• ERK signaling dissolves ERF repression condensates in living embryos

Weaver CJ, Patel AL, Shvartsman SY, Levine M, Treen N.

PNAS 2022. Mar 1; 119(9), e2119187119

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• Genome organization controls transcriptional dynamics during development.

Batut PJ, Bing XY, Sisco Z, Raimundo J, Levo M, Levine M.

Science 2022. Feb 3; 375, 6580,566-570

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• Neuronal identities derived by misexpression of the POU IV sensory determinant in a protovertebrate.

Paul PC, Horie R, Kusakabe T, Sasakura Y, Singh M, Horie T, Levine M.

PNAS 2022. Jan 18; 119(4),e2118817119

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2021

• The hypothalamus predates the origin of vertebrates.

Lemaire LA*, Cao C*, Yoon PH, Long JJ, Levine M.

Science Advances 2021. Apr 28; Vol. 7, no. 18, eabf7452

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• Properties of repression condensates in living Ciona embryos.

Treen N., Shimobayashi F. S., Eeftens J., Brangwynne P. C., Levine M.

Nat. Commun. 2021. Mar 10; 12, 1561

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2020

• SnapShot: The Regulatory Genome.

Bing X.Y., Batut P. J., Levo M., Levine M., Raimundo J.

Cell. 2020.Sep 9; 182, 1674-1674.e1

​

2019

• Large distances separate coregulated genes in living Drosophila embryos.

Heist T., Fukaya T. & Levine M.

Proc Natl Acad Sci U S A 2019 July 23; 116, 15062-15067

​

• Comprehensive single-cell transcriptome lineages of a proto-vertebrate.

Cao C*, Lemaire LA*, Wang W, Yoon PH, Choi YA, Parsons LR, Matese JC, Wang W, Levine M, Chen K​.

Nature. 2019. Jul 10; 571, 349–354

​

2018

• Regulatory cocktail for dopaminergic neurons in a protovertebrate identified by whole-embryo single-cell transcriptomics.

Horie T*, Horie R*, Chen K*, Cao C*, Nakagawa M, Kusakabe TG, Satoh N, Sasakura Y, Levine M​.

Genes Dev. 2018. Oct 1;32(19-20):1297-1302

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• Developmental enhancers and chromosome topology.

Furlong, E. E. M. & Levine, M.

Science 2018 Sep 28: 361, 1341-1345

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• Shared evolutionary origin of vertebrate neural crest and cranial placodes.

Horie R*, Hazbun A*, Chen K*, Cao C, Levine M, Horie T.

Nature. 2018 Aug; 560(7717): 228-232.

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• Temporal dynamics of pair-rule stripes in living Drosophila embryos.

Lim B, Fukaya T, Heist T, Levine M.

PNAS. 2018 Aug;115(33): 8376-8381.

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• Visualization of Transvection in Living Drosophila Embryos.

Lim B*, Heist T*, Levine M, Fukaya T.  

Mol Cell. 2018 Apr 19;70(2): 287-296.

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• Depletion of Maternal Cyclin B3 Contributes to Zygotic Genome Activation in the Ciona Embryo.

Treen N, Heist T, Wang W, Levine M.  

Curr Biol. 2018 Apr 23;28(8):1330-1331.

​

2017

• Transvection - quick guide.

Fukaya T and Levine M.  

Curr Biol. 2017.​ Oct 9; 27(19), R1047-R1049.

​

• Rapid rates of Pol II elongation in the Drosophila embryo.

Fukaya T*, Lim B*, Levine M.  

Curr Biol. 2017.​ May 8; 27(9), 1387-1391. 

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• Uncoupling neurogenic gene networks in the Drosophila embryo.

Rogers WA*, Goyal Y*, Yamaya K, Shvartsman SY, Levine M.

Genes Dev. 2017. April 1; 31(7), 634-638. 

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• Transcriptional pre-patterning of Drosophila gastrulation.

Lim B, Levine M, Yamazaki Y.

Curr Biol. 2017. Jan 23; 27(2):286-290.

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2016

​

• Nodal and FGF coordinate ascidian neural tube morphogenesis.

Navarrete IA, Levine M.

Development. 2016. Dec 15; 143(24):4665-4675.

​

• Enhancer control of transcriptional bursting.

Fukaya T*, Lim B*, Levine M.

Cell. 2016. Jul 14;166(2):358-68.

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• Mitosis-associated repression in development.

Esposito E, Lim B, Guessous G, Falahati H, Levine M.

Genes Dev. 2016. Jul 1;30(13):1503-8.

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• Syntax compensates for poor binding sites to encode tissue specificity of developmental enhancers.

Farley EK, Olson KM, Zhang W, ROkshar DS, Levine MS.

PNAS. 2016. Jun7;113(23):6508-13.

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• Shadow enhancers mediate dynamic shifts of gap gene expression in the Drosophila embryo.

El-Sherif E, Levine M.

Curr Biol. 2016. May 9;26(9): 1164-9.

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• Transcriptional Memory in the Drosophila Embryo.

Ferraro T, Esposito E, Mancini L, Ng S, Lucas T, Coppey M, Dostatni N, Walczak AM, Levine M, Lagha M.

Curr Biol. 2016. Jan 25;26(2):212-8.

 

2015

​

• Suboptimization of developmental enhancers.

Farley EK, Olson KM, Zhang W, Brandt AJ, Rokhsar DS, Levine MS.

Science. 2015. Oct 16;350(6258):325-8.

 

• The pre-vertebrate origins of neurogenic placodes.

Abitua PB, Gainous TB, Kaczmarczyk AN, Winchell CJ, Hudson C, Kamata K, Nakagawa M, Tsuda M, Kusakabe TG, Levine M.

Nature. 2015. Aug 27;524(7566):462-5.

 

• Diverse ETS transcription factors mediate FGF signaling in the Ciona anterior neural plate.

Gainous TB, Wagner E, Levine M.

Dev Biol. 2015. Mar 15;399(2):218-25.

 

• An interview with Mike Levine.

Levine M, Vicente C.

Development. 2015. Oct15;142(20):3453-5.

 

• Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo.

Bothma JP, Garcia HG, Ng S, Perry MW, Gregor T, Levine M.

Elife. 2015. Aug12;4.

 

• ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervous system.

Oktaba K, Zhang W, Lotz TS, Jun DJ, Lemke SB, Ng SP, Esposito E, Levine M, Hilgers V.

Mol Cell. 2015

​

2014

 

• Retrospective. Walter Gehring (1939-2014).

Levine M.

Science. 2014

 

• Dynamic regulation of eve stripe 2 expression reveals transcriptional bursts in living Drosophilaembryos.

Bothma JP, Garcia HG, Esposito E, Schlissel G, Gregor T, Levine M.

Proc Natl Acad Sci U S A. 2014

 

• Ephrin-mediated restriction of ERK1/2 activity delimits the number of pigment cells in the CionaCNS.

Haupaix N, Abitua PB, Sirour C, Yasuo H, Levine M, Hudson C.

Dev Biol. 2014

 

• Islet is a key determinant of ascidian palp morphogenesis.

Wagner E, Stolfi A, Gi Choi Y, Levine M.

Development. 2014

 

2013

​

• Development: lights, camera, action--the Drosophila embryo goes live!

Bothma J, Levine M.

Curr Biol. 2013

 

• p120RasGAP mediates ephrin/Eph-dependent attenuation of FGF/ERK signals during cell fate specification in ascidian embryos.

Haupaix N, Stolfi A, Sirour C, Picco V, Levine M, Christiaen L, Yasuo H.

Development. 2013

 

• Computing away the magic?

Levine M.

Elife. 2013

 

• Paused Pol II coordinates tissue morphogenesis in the Drosophila embryo.

Lagha M, Bothma JP, Esposito E, Ng S, Stefanik L, Tsui C, Johnston J, Chen K, Gilmour DS, Zeitlinger J, Levine MS.

Cell. 2013

 

• Temporal regulation of single-minded target genes in the ventral midline of the Drosophila central nervous system.

Hong JW, Park KW, Levine MS.

Dev Biol. 2013

 

• Rapid transcription fosters coordinate snail expression in the Drosophila embryo.

Boettiger AN, Levine M.

Cell Rep. 2013

​

2012

 

• Identification of a rudimentary neural crest in a non-vertebrate chordate.

Abitua PB, Wagner E, Navarrete IA, Levine M.

Nature. 2012

 

• Precision of hunchback expression in the Drosophila embryo.

Perry MW, Bothma JP, Luu RD, Levine M.

Curr Biol. 2012

 

• FGF signaling establishes the anterior border of the Ciona neural tube.

Wagner E, Levine M.

Development. 2012

 

• ELAV mediates 3' UTR extension in the Drosophila nervous system.

Hilgers V, Lemke SB, Levine M.

Genes Dev. 2012

 

• Transcriptional repression via antilooping in the Drosophila embryo.

Chopra VS, Kong N, Levine M.

Proc Natl Acad Sci U S A. 2012

 

• HOT DNAs: a novel class of developmental enhancers.

Farley E, Levine M.

Genes Dev. 2012

 

• The snail repressor inhibits release, not elongation, of paused Pol II in the Drosophila embryo.

Bothma JP, Magliocco J, Levine M.

Curr Biol. 2011

 

• Neural tube patterning by Ephrin, FGF and Notch signaling relays.

Stolfi A, Wagner E, Taliaferro JM, Chou S, Levine M.

Development. 2011

 

• Neural-specific elongation of 3' UTRs during Drosophila development.

Hilgers V, Perry MW, Hendrix D, Stark A, Levine M, Haley B.

Proc Natl Acad Sci U S A. 2011

​